General Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/ADORA2A/G15 Stable Cel
Recombinant CHO-K1 cells stably overexpress human adenosine A2A receptor (ADORA2A) on the surface and contain high levels of G protein G s to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/CysLT1/G15 Stable Cell
CysLT1 (Cysteinyl leukotriene receptor 1) is previous named as LTD4 receptor (leukotriene D4 receptor) It is a receptor for cysteinyl leukotrienes and has highest affinity to leukotriene D4 (LTD4) The receptor mediates contraction and proliferation of smooth muscle edema eosinophil migration and damage to the mucus layer in the lung caused by LTD4 A CysLT1 selective antagonist montelukast is used clinically in the treatment of asthma This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system The rank order of affinities for the leukotrienes is LTD4 LTE4 LTC4 LTB4
Genscript Corporation CHO-K1/mouse PD-L1 Stable Cell
Recombinant CHO-K1 cells stably overexpress mouse programmed cell death 1 ligand 1 (PD-L1) on the surface The surface expression of PD-L1 is validated by FACS analysis
Genscript Corporation CHO-K1/ADRA2C/G15 Stable Cell
The adrenoceptors ADRA2C is expressed in the brain kidney aorta lung skeletal muscle heart and spleen ADRA2C knockout mice exhibited disrupts presynaptic inhibition of noradrenaline release at low stimulation frequencies
Genscript Corporation CHO-K1/KIR Stable Cell Line
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and are subsets of T cells The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM) while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals The ligands for several KIR proteins are subsets of HLA class I molecules thus KIR proteins are thought to play an important role in regulation of the immune response
Genscript Corporation CHO-K1/ADORA1/G15 Stable Cell
A1 is a receptor for adenosine It is demonstrated that the A1 receptor is ubiquitous throughout the entire body Activation of A1 elicits an inhibition of adenylate cyclase and therefore a decrease in the cAMP concentration A1 receptors are implicated in sleep promotion by inhibiting wake promoting cholinergic neurons in the basal forebrain Adenosine antagonists are widely used in neonatal medicine
Genscript Corporation CHO-K1/ mouse PD-1 Stable Cell
Programmed cell death protein 1 also known as PD-1 and CD279 (cluster of differentiation 279) is a protein that in humans is encoded by the PDCD1 gene PD-1 functioning as an immune checkpoint plays an important role in down regulating the immune system by preventing the activation of T-cells which in turn reduces autoimmunity and promotes self-tolerance The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells)
Genscript Corporation CHO-K1/OPRM1/G15 Stable Cell
Recombinant CHO-K1 cells stably overexpress human opioid receptor mu 1 (OPRM1) on the surface and contain high levels of G protein G i and G q to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/H4/G15 Stable Cell Lin
Recombinant CHO-K1 cells stably overexpress human histamine receptor H4 (H4) on the surface and contain high levels of G protein G i to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/Mouse VISTA Stable Cell
V-domain Ig suppressor of T cell activation (VISTA) is a potent negative regulator of T-cell function that is expressed on hematopoietic cells VISTA levels are heightened within the tumor microenvironment in which its blockade can enhance antitumor immune responses in mice In humans blockade of the related programmed cell death 1 (PD-1) pathway has shown great potential in clinical immunotherapy trials
Genscript Corporation CHO-K1/GPBAR1 Stable Cell Line
The gene GPBRA1 encodes G protein-coupled bile acid receptor Bile acid-binding induces its internalization activation of extracellular signal-regulated kinase and intracellular cAMP production
Genscript Corporation CHO-K1/EDNRB Stable Cell Line
In mammals the endothelin (ET) family comprises three endogenous isoforms ET-1 ET-2 and ET-3 These endothelium-derived peptides perform their functions via two endothelin receptors classified as EDNRA and EDNRB EDNRB receptors present on the endothelial cells lining the vessel wall and play a role in the release of endothelium-derived relaxing factors such as nitric oxide (NO) and prostanoids and in removing ET from the circulation
Invivogen THP1-DL KO-MDA5 3-7X10E6 CELLS
Human THP-1 Monocytes - MDA5 knockout NF-B-SEAP and IRF-Lucia Reporter Cells
Genscript Corporation CHO-K1/Cyno CD47 Stable Cell L
This gene encodes a membrane protein which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin and it may play a role in membrane transport and signal transduction This gene has broad tissue distribution and is reduced in expression on Rh erythrocytes Alternatively spliced transcript variants have been found for this gene
Biochain Institute Inc Paraffin Tissue Section - Human Diabetic Diseased Tissue: Colon, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
